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Description

Following oral, intravenous, or intraperitoneal administration, curcumin is predominantly metabolized to glucuronide and sulfate conjugates in the liver and excreted via bile into the gastrointestinal tract (176, 177)

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Free copper is extremely reactive through Fenton chemistry, and it stimulates the secretion of pro-inflammatory cytokines such as interleukin-1 (IL-1), IL-4, and tumor necrosis factor (TNF) in both the brain and the blood (Tokuda et al., 2009)

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