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Friedman TC, Garcia-Borreguero D, Hardwick D, et al

This metabolic shift creates a cascade of effects: stabilizing glucose levels that would otherwise fluctuate dramatically, reducing neuroinflammation that contributes to pain sensitivity, and providing ketones as an alternative fuel source for brain cells that may be experiencing energy deficits during migraine attacks

At the atomic level, dynamic conformations of TLR signaling complexes can be resolved through cryo-microscopy (cryo-EM) and artificial intelligence (AI) simulation [426, 427]

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