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Verma et al., 2021) or related dysfunctions such as higher blood plasma concentrations of low-density lipoprotein (LDL- cholesterol), low high-density lipoprotein (HDL-cholesterol), and insulin resistance (Lira et al., 2010
Its not a perfect measure, but doctors use it to help decide who qualifies
TRIUMPH-4 (Phase 3, 68 weeks) 12mg dose: 28.7% weight loss (~71 lbs / 32 kg average) 9mg dose: 26.4% weight loss (~64 lbs / 29 kg average) Patients also saw 76% reduction in knee osteoarthritis pain Blood pressure reduced by 14 mmHg on average Source: ClinicalTrials.gov (TRIUMPH-4, NCT05931367) The TRIUMPH Phase 3 program includes 4 trials studying retatrutide for obesity, type 2 diabetes, and cardiovascular outcomes
Because IGF-1 is part of this pathway, candidacy screening and follow-up testing exist to keep the approach within a safe range for you specifically
De Vijlder HC, Westerhof W, Schreuder GM, et al: Difference in pathogenesis between vitiligo vulgaris and halo nevi associated with vitiligo is supported by an HLA study, Pigment Cell Res 17:270274, 2004
