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Niacinamide: Decreases hyperpigmentation and lightens skin gradually after using it for a long duration
doi:10.1016/j.eurger.2017.01.002
Fidock DA, Rosenthal PJ, Croft SL, Brun R, Nwaka S (2004) Antimalarial drug discovery: efficacy models for compound screening
It is a clinical decision based on objective measurements from a baseline workup
Even more impressive, they also got GLP-1 increases -- almost identical changes, from threefold baseline up to sixfold, with extended duration
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