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Vitamin B12 injections are generally safe, but some individuals may experience side effects, including: Pain or redness at the injection site Mild diarrhea Itching Nausea or vomiting Dizziness or headaches Hot flashes In rare cases, more serious reactions, such as allergic responses (rash, swelling, trouble breathing), can occur

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Both involve inflammation of the intestinal tract, but they differ in where and how the inflammation occurs