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Both preclinical (in vitro and in vivo) and clinical studies were considered for inclusion to provide a broad perspective on the current state of evidence
Shift 2: Off-label GLP-1 use for obesity became explicitly excluded
West says more assessments of peoples weight and health reversals after they stop treatment conducted outside of the clinical trials would help researchers fully understand whats happening
Eligible study designs included RCTs, open-label studies, non-randomized studies, and observational studies
Estrogen and GLP-1: the deeper science For those who want to understand the mechanism at a deeper level, the interplay between estrogen and GLP-1 signaling is one of the most fascinating areas of current metabolic research
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