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A hybrid quantum mechanics/molecular mechanics (QM/MM) method was established to model the reaction energies of each cysteine with H 2 O 2 (Supplementary methods) According to this method, the activation energy ( E a ) for oxidization of deprotonated GLRX cysteine residues follows the following trend: E a (C8) E a (C83) Ser (15.977 Da (C) and S-glutathionylation (+305.068 Da)
According to the authors, the risk of blindness appeared to be greatest within the first year of starting semaglutide treatment, and the total risk was higher compared to other therapies
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According to the transcripts per million reads (FPKM) method, the gene expression levels of transcript were calculated to further identify the differential expression genes (DEGs) between two groups
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