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That increased pressure and prolonged acid exposure cause reflux in 1015% of patients, especially during dose increases
Kidney function, liver status and drug interactions also shape selection
Besides lowering glucose, GLP-1RAs have beneficial effect on heart, brain, and pancreas, according to an international team that conducted the semaglutide trial
They found there was not enough evidence for causality, but noted there was a complex interplay between mental illness and chronic endocrine disorders for which GLP-1 RAs may be used for treatment
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