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In accordance with at least some embodiments, the polar hydrophilic ligands suitable for the present technology contain at least one of the following functional groups: hydroxyl, carboxylic acid, amine (primary or secondary), ketone or aldehyde, acetyl halide, phosphate, phosphono, sulfate, sulfonyl, sulfonamide, and thiol

Berman E, Arlin AZ, Gee TS, Kempin SJ, Mertelsmann R, Andreeff M , Nahmias N, Clarkson BD

In HPG axis terms, peptideinduced increases in IGF1 may blunt central inhibitory signals and re-establish more youthful gonadotropin rhythms