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Underlying medical conditions: Certain conditions can blunt weight loss responses, including hypothyroidism (a thyroid function test is advisable if not recently checked), Cushing's syndrome or exogenous corticosteroid use, polycystic ovary syndrome (PCOS), and obstructive sleep apnoea (OSA)
Choose evidence-backed delivery: see the PlexusDx Weight Management Protocols for semaglutide and tirzepatide in injection and oral formats
Finally, weight loss that actually lasts GLP-1 medications help you lose weight, keep it off, and feel amazing doing it
However, choosing the right weight loss method can often feel overwhelming
Within-class differences further inform selection, as GLP-1RAs are more strongly associated with reductions in atherosclerotic events, while SGLT2is demonstrate greater benefit in HF and kidney outcomes, with modest blood pressure-lowering effects that may contribute to cardiovascular risk reduction [9]
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