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Florence Comite, a longevity doctor who serves concierge medicine clients in New York City, told Business Insider

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In a head-to-head open-label trial reported in February 2026, average weight loss at 84 weeks favored tirzepatide, and the sponsor noted CagriSema did not meet its prespecified non-inferiority target against tirzepatide

Absorption profiles The absorption of a drug into the bloodstream is a critical factor in its overall efficacy