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7.1 pH) and washed with mitochondrial respiration medium MiRO5Cr (EGTA (0.5 mM), MgCl 2 (3 mM), lactobionic acid (60 mM), taurine (20 mM), potassium dihydrogen phosphate (10 mM), HEPES (20 mM), d-sucrose (110 mM), BSA fatty-acid-free (0.1%) and supplemented with creatine (20 mM) right before use) before homogenization

This method allows one to adapt slowly to the substance and reduce the likelihood of adverse reactions and maximize the potential benefits

This personalized data helps optimize whether tirzepatide or another GLP-1 therapy will deliver the best results for your genetic makeup

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5i) or insulin levels (Extended Data Fig