For protocol design: Daily dosing is the standard research convention
In addition, the side effects recorded in clinical trials of GLP-1RAs development programs, nausea and vomiting, prolonged the launch of the drugs (3, 4) Liraglutide and semaglutide are two of the most potent GLP-RAs
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Preclinical studies in rodent models demonstrate that GLP-1RAs, including exenatide, liraglutide, and semaglutide, attenuate alcohol-induced dopamine release in the NAc, reducing the reinforcing properties of alcohol [44]