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GLP-1 agonists (and dual agonists) don't cause significantly more muscle loss than calorie restriction alone
In the STEP-1 trial, 1,961 patients were followed for 68 weeks and underwent randomization to semaglutide or placebo plus lifestyle intervention resulting in14.9% weight loss in the semaglutide group versus 2.5% in the placebo group [33]
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Rotate injection sites each time to prevent lipohypertrophy (fatty lumps under the skin)
doi: 10.1128/AAC.00888-13 105 CorrSCLiYRiedelCUO'ToolePWHillCGahanCGM
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