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Presented for research literature review only Uysal M et al
James Chen, along with Dan Stetson from the University of Washington working independently, demonstrated that the DNA accumulation observed in mice deficient in three prime repair exonuclease 1 (TREX1)an enzyme responsible for degrading cytoplasmic DNA, including that derived from damaged organelles such as mitochondria or nucleimediates its pathogenic effects through cGAS
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