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doi: 10.1161/CIRCULATIONAHA.107.739938 53 NystrmT
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Fat mass decreased by 17.0 kg with the combination, compared to 3.4 kg with the placebo, whereas lean mass decreased by 8.4 kg, compared to 2.6 kg
While the models share hormonal changes and satiety impairments, Bbs5 / mice displayed a unique immune profile characterized by elevated macrophages, a skewed M1/M2 balance, and Tregs with Th17-like phenotypes, resulting in a proinflammatory signature
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