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The 8 to 12 week on / 4 to 8 week off pattern is extrapolated from pharmacological principles and community experience, not from controlled trials
Additional information on the synthesis of the GLP-1 analogues and their characterizations is available in the Supplementary data (Supplementary Methods and Supplementary Figs
These compounds are nontoxic, water-soluble, and rapidly excreted in the urine
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