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In patients with type 2 diabetes at high cardiovascular risk, semaglutide demonstrated significantly lower rates of cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke compared to placebo, establishing the noninferiority of semaglutide

The only difference is the FDA-approved indication, not the dosing protocol

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They typically use simplified pharmacokinetic models (often one-compartment, first-order kinetics) that may not fully capture the complexity of tirzepatide's behavior in the body