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V.SignorC.da Silva BernardiJ.et al (2019)
In ADCs, acid-labile groups leverage the acidic microenvironment of tumor cells or intracellular lysosomes to achieve precise drug release, enhancing targeting and reducing systemic toxicity
The gamma-glutamyl cycle does allow some tissues (particularly the liver, kidney, and lung epithelium) to utilize extracellular glutathione more directly via membrane transporters
this can have significant positive effects as discussed above
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