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The dual GIP/GLP-1 mechanism of tirzepatide creates a slightly different side effect pattern
Science 6 BradyG.CreanS
Ferguson, G
It feels like a reasonable meal, but it's spiking your insulin right before the single longest fasting window of your entire day." When you sleep, your body is supposed to shift into fat-burning mode, the GLP-1 is still swimming around your body, and your insulin drops
PMID:2852955 [4] Levine N, Sheftel SN, Eytan T, Dorr RT, Hadley ME, Weinrach JC, Ertl GA, Toth K, McGee DL, Hruby VJ
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