Tirzepatide is contraindicated in patients with a personal or family history of MTC or MEN2, and in those with serious hypersensitivity to the medication
The national healthcare claims database managed by the government, such as NHIS-HEALS, covers approximately 98% of the population of South Korea and can be used for research
Large-scale research data, including pooled data from three randomized double-blind placebo-controlled cardiovascular outcome trials, and a nationwide Danish registry-based cohort in over 120,000 patients, suggests GLP-1s reduce the incidence of dementia, especially in patients with type 2 diabetes [19]
One consequence of this is impairment of the urea cycle, exacerbating hyperammonemia
3.1.3 Phospholipid oxidation products and inflammatory signaling Oxidized phospholipids generated through peroxidation, such as hydroxylated lipids and keto-lipids, not only compromise the integrity of the cell membrane directly but also increase membrane tension in tandem with enhanced lipid peroxidation