Food and Drug Administration (FDA) database from 2004 to 2009 reported increased risks of pancreatic and thyroid cancer associated with the GLP-1 receptor agonist (GLP-1RA) exenatide compared to other therapies [8]
On the other hand, DPP-4, the incretin degrading endopeptidase, has been found to be reduced in tissue and plasma in active CD (170) and further inhibition of DPP-4 accelerated mucosal healing in a murine model of colitis (171)
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For data that were normally distributed and homogeneous, parametric tests were used, specifically one-way ANOVA followed by Tukeys post hoc test