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Indeed, the first pass effect, or the extent to which a drug is metabolized by intestinal, hepatic, and microbial enzymes, is ultimately what determines the bioavailability of a drug (how much reaches circulation) and is subject to considerable variability depending on the presence or absence of certain microbes and enzymes

Interestingly, cysteine deprivation and activation of necroptosis are associated with the augmented activity of glutaminolysis [231], which fuels the mitochondrial Krebs cycle through the conversion of glutamate to -ketoglutarate [232]

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10.1038/s41598-022-14272-0 79 KangJ