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The goal is to help patients remain on an effective therapy long enough to achieve sustained metabolic and cardiovascular benefit without unnecessary interruption

at high doses, it overwhelms and glucuronidation/CYP2E1 take over) Bile acids Catecholamines (dopamine, norepinephrine, epinephrine) Cholesterol DHEA and steroid hormones Estrogens Minoxidil (requires sulfation for activation) Thyroid hormones Sulfation is not always detoxifying

thus, higher levels may increase sexual function in men

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