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*Correspondence: Gang Liu [email protected] These authors have contributed equally to this work This article was submitted to Animal Reproduction - Theriogenology, a section of the journal Frontiers in Veterinary Science ORCID: Shubin Li orcid.org/0000-0002-6865-9667 Jingyu Ren orcid.org/0000-0002-0048-3052 Wenqi Zhang orcid.org/0000-0003-4891-500X Yanfeng Dai orcid.org/0000-0001-7147-1748 Gang Liu orcid.org/0000-0002-5180-3765 Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

These NAD + -dependent deacetylases regulate mitochondrial biogenesis through transcriptional players such as the peroxisome proliferator-activated receptor gamma coactivator 1- (PGC-1), as well as pathways involved in DNA repair and redox balance [253, 254]

Typically, this irritation leads to an inflammatory response, but administering BPC-157 beforehand seemed to lessen that response in a dose-dependent manner [6]

209,210 For targeted NADs, including ASO and siRNA, when the relevant genetic information of the disease is determined, lead compounds can be designed for the gene sequence to avoid off-target effects during development

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