Then in May 2025, the first direct head-to-head trial SURMOUNT-5 was published in the New England Journal of Medicine , putting the two medications head-to-head in the same patients, at the same time, under the same conditions
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A study published in the journal Sleep found that people who are sleep-deprived consume more and unhealthier snacks between meals, which can contribute to weight gain, plus report higher levels of hunger
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GLP-1 receptor agonists like semaglutide (Wegovy), tirzepatide (Zepbound), and liraglutide (Saxenda) work through multiple mechanisms to improve blood sugar control and promote weight loss