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It also spares the use of amino acids as energy sources during exercise, making them potentially available for new protein synthesis [4] and decreases the accumulation of lactate

Lancet Diabetes Endocrinol 6:605617 Mosenzon O, Blicher TM, Rosenlund S, Eriksson JW, Heller S, Hels OH et al (2019) Efficacy and safety of oral semaglutide in patients with type 2 diabetes and moderate renal impairment (PIONEER 5): a placebo-controlled, randomised, phase 3a trial

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Before ferroptosis was conceptualized, studies had already detected reduced GPX activity and GSH levels in the cerebrospinal fluid (CSF) of patients (Suzuki et al., 1983)