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Using an injectable medicine beyond 28 days after first puncture is risky

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2014 Oct;16(5):705-15

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What we do have is a growing body of evidence suggesting these medications may address several of the most common and difficult-to-treat problems in EDS through different but complementary pathways: mast cell-mediated inflammation, mechanical joint burden from weight, and sleep-disordered breathing

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The researchers also noted that 23.5% (95% CI, 22.3-24.8) of people meeting FDA indications for tirzepatide reported using medications that may slow gastrointestinal motility, which could increase gastrointestinal adverse effects when combined with any GLP-1 receptor agonist

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