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The mechanisms behind the renoprotective effects of GLP-1 RAs involve anti-albuminuric, anti-inflammatory, natriuresis, anti-atherogenic, and anti-oxidant effects through protein kinase A signaling, induction of natriuresis by inhibiting sodium-hydrogen exchanger 3, and a reduction in hyperfiltration 27,30,31
Stable gastric pentadecapeptide BPC 157, safe in clinical trials, may solve major health problems
Early identification through testing is important, as insulin resistance is largely asymptomatic until complications develop
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