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The process of cellular senescence involves multiple factors, including DNA damage, telomere shortening, and epigenetic changes, which lead to cell cycle arrest and ultimately result in cellular senescence (Zhang et al., 2024)

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Assessment of the relatedness of each AE with respect to study drugs was determined by the treating physician, and the AE, as assigned by the study investigator, was classified using the MedDRA version 19.0 system organ class and preferred term

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