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[11] There is insufficient evidence to conclude that B12 supplementation directly alters sleep architecture in healthy individuals with adequate B12 levels
For people with an MTHFR mutation, methylcobalamin (as opposed to other forms of B12) is therapeutic
[4] Based on animal research, it is thought that the increased methylmalonyl-CoA hydrolyzes to form methylmalonate (methylmalonic acid), a neurotoxic dicarboxylic acid, causing neurological deterioration
Additionally, standard injection risks (infection at injection site, vein irritation for IV, etc.) apply, though proper sterile technique makes these complications uncommon
By inhibiting NNMT, it alters the balance of S-adenosylmethionine (SAM) and nicotinamide metabolism, affecting DNA methylation patterns and histone modifications
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