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Orforglipron, a once-daily oral GLP-1 pill, led to an average weight loss of 11.2% over 72 weeks, along with improvements in blood pressure, triglycerides, and cholesterol
High doses may increase TMAO (trimethylamine-N-oxide), a compound linked to cardiovascular risk
Nature 2011 472(7341):57 - 63 K
Together, these modifications produce a compound with substantially lower systemic plasma clearance than GHRP-6 approximately five-fold lower and moderate resistance to metabolic degradation, resulting in a more sustained and reproducible GH secretory response
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