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For patients interested in participating in research , the following resources may be helpful: NIHR Be Part of Research (bepartofresearch.nihr.ac.uk) search for Parkinson's and GLP-1 trials Parkinson's UK (www.parkinsons.org.uk) information on current research and trial opportunities When to contact your GP or specialist : If you have Parkinson's disease and diabetes, and wish to discuss whether a GLP-1 receptor agonist is appropriate for your diabetes management If you experience new or worsening symptoms whilst taking any medication If you are interested in clinical trial participationyour neurologist can advise on suitable studies Seek urgent medical attention if you experience: Severe, persistent abdominal pain (possible pancreatitis) Persistent vomiting or inability to keep fluids down (risk of dehydration) Signs of dehydration (extreme thirst, dark urine, dizziness) Allergic reaction (rash, swelling, difficulty breathing) Patients should never start, stop, or modify medications without medical supervision

This is especially relevant for GLP-1 users who report feeling like the stool is right there but will not come out, or who experience excessive straining despite having soft stool

BCAAs, when taken in conjunction with resistance training, provide key building blocks for muscle protein synthesis, help maintain net muscle protein balance, and increase muscle mass

In the case of whole blood, the sample would be directly extracted in 5% MPA

Prespecified positive and negative controls To evaluate the validity of our approach, we conducted analyses using both positive and negative outcome and exposure controls