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In Summary GLP1 medications do more than reduce appetitethey reshape gut microbiota
In intact HepG2 cells, the pan-flavoenzyme inhibitor, DPI, prevented the NFT-stimulated increase in glutathione levels, indicating the involvement of one or more of these enzymes in NFT-dependent activation of Nrf2 (Fig
2013 Jun;19(2):165-72
Allulose, by contrast, doesn't cause blood sugar spikes, which keeps insulin levels at bay, and may therefore help improve insulin sensitivity
In the JAMA paper: expression of the GLP-1 receptor in the human optic nerve and GLP-1 RAinduced enhanced sympathetic nervous system activity might influence optic nerve head perfusion. =Rapid lowering of blood glucose (and rapid change in metabolic state) in persons with pre-existing retinopathy may worsen ocular microvascular conditions (though this is more established with insulin rather than semaglutide specifically)
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