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Studies with PYY agonists administered intravenously have shown reduction in food intake with increased satiety [92, 93], however, a nasal PYY agonist showed minimal efficacy with poor tolerability [94]
GLP-1RAs, particularly Liraglutide exert protective effects by suppressing inflammasome activation and downstream pyroptotic responses.In H9c2 cells
Retatrutide is an investigational triple receptor agonist that simultaneously targets the glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon receptors
Two commonly referenced comparison compounds are semaglutide and tirzepatide, which represent single receptor and dual receptor incretin agonist designs respectively
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