Tesamorelin is an FDA-approved synthetic GHRH analog used to reduce visceral fat in HIV-associated lipodystrophy and reliably increases GH and insulin growth factor 1 (IGF-1)
The skin acts as a barrier and stops them from being absorbed in useful amounts
For those not breastfeeding, GLP-1 medicines can be effective tools to support weight loss or manage diabetes, but they do come with side effects the most common being nausea, vomiting and diarrhoea
Elevated circulating IGF-1 inhibits GHRH secretion and directly suppresses somatotroph GH release, reducing endogenous IGF-1 synthesis for the duration of IGF-1 LR3 administration
Ravi Sankar Erukulapati, senior consultant endocrinologist, Apollo Hospitals, Jubilee Hills, Hyderabad, points to our sarcopenic obesity low muscle mass and higher fat mass, which worsens insulin resistance