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The increase in the incidence of cancer, diabetes, cardiovascular disease, and psychiatric disorders (7072), might also be related to disruption of sleep-wake rhythms, impaired secretion of melatonin from nighttime light, combined with obesity and a tendency to produce reactive oxygen species (73), which also affects the circadian rhythm of GLP-1 secretion
Clinical evidence: The SURMOUNT-1 trial, published in the New England Journal of Medicine , showed that participants on the highest dose of tirzepatide (15 mg) lost an average of 22.5 percent of their body weight over 72 weeks the most weight loss ever demonstrated by a pharmaceutical agent in a clinical trial (Jastreboff et al., 2022)
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