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The is remarkably constant in an oral dose range from 1 to 100,000 g of hydroxocobalamin

The safety profile appears similar to other peptide medications in the metabolic class

A case report of a patient with HER2-expressing NEPC with rapid progression on seven different lines of therapy demonstrated substantial response on off-label treatment with T-DXd, including a 57% overall reduction in tumor volume across sites of metastases and improved performance status 171

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