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PMC4508379
A.RiegT
Decreased glucagon-like peptide-1 correlates with abdominal pain in patients with constipation-predominant irritable bowel syndrome
Melanotan 2 appears to be able to help combat that negative effect in men, with more research needed on its effect on sexual desire in women
12,13 Although the original approval was largely based on the potent glucose-dependent insulinotropic properties of GLP-1R activation on pancreatic -cells, it has become clear that the GLP-1R is expressed on a variety of other tissues, which produce a range of biological effects across diverse organ systems (Figure 2)
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