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Consequently, this intervention reduces the accumulation of histone lactylation and suppresses the expression of Fas, ultimately alleviating necroptotic cell death and renal impairment in DKD models ( 4 Autophagy 4.1 Autophagic signaling pathway Autophagy represents a preserved cellular mechanism by which cytoplasmic materials are engulfed within autophagosomes for lysosomal degradation and recycling (140)
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