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routine use outside EPP is not currently supported by robust randomized data

Klausen MK, Thomsen M, Wortwein G, et al

Weight management for prevention or management of type 2 diabetes There is strong and consistent evidence that obesity management can delay the progression from prediabetes to type 2 diabetes and is highly beneficial in treating type 2 diabetes, new guidance states

Participants receiving once daily doses of the oral tablet formulation of VK2735 demonstrated reductions in mean body weight after 13 weeks, ranging up to 12.2% from baseline

The clinical implications, however, depend on whether the mechanism translates to humans and whether the doses used produce meaningful c-Met activation in human brain tissue