Nausea Another side effect that could affect your energy levels is nausea
What it is Retatrutide is an investigational triple-agonist peptide designed to simultaneously activate three receptors: the glucose-dependent insulinotropic polypeptide receptor (GIPR), the glucagon-like peptide-1 receptor (GLP-1R), and the glucagon receptor (GCGR)
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Pure GLP-1 receptor agonists work through four mechanisms: Slowed gastric emptying (the primary satiety signal) Increased insulin secretion in response to glucose Reduced glucagon secretion (glucagon raises blood sugar) Central appetite suppression via hypothalamic GLP-1 receptors The weight loss ceiling for pure GLP-1 agonists appears to be around 15% to 17% of baseline body weight at maximum tolerated dose over 68 weeks (the STEP 1 and STEP 5 trial endpoints for semaglutide 2.4 mg)
Side Effects Common side effects may include: Nausea or vomiting Diarrhea or constipation Decreased appetite Abdominal pain Rare but serious side effects include: Severe allergic reactions, such as rash, swelling, or difficulty breathing Pancreatitis, indicated by severe abdominal pain or vomiting Kidney problems, such as reduced urination or swelling in the legs If any side effects persist or worsen, consult your healthcare provider immediately
