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Protein restriction may contribute to perturbations in cellular protein homeostasis, resulting in GCN2-mediated, ATF4-dependent activation of FGF21 expression (84)
Melatonin protects the heart and pancreas by improving glucose homeostasis, oxidative stress, inflammation and apoptosis in T2DM-induced rats
Luan Y, Ren X, Zheng W, Zeng Z, Guo Y, Hou Z, et al
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The allowance for investigators to use all available information (for example, concomitant medication) to assess glycemic category was primarily included to account for scenarios in which glucose-lowering medications were initiated during the trial that would confound glycemic category assessment if based purely on fasting plasma glucose or HbA 1c levels (for example, if a patient developed diabetes during the study and received a glucose-lowering drug that resulted in their glucose level being below the American Diabetes Association threshold for type 2 diabetes diagnosis)
