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GLP-1 is secreted by the neuroendocrine L cells in the ileum, while GIP is secreted by K cells in the duodenum and jejunum
S1 shows a schematic of the subject selection procedure
Unlike Novos GLP-1 agonists, these are dual agonists, as they activate GLP-1 as well as the hormone glucose-dependent insulinotropic polypeptide (GIP), which plays a role in lipid metabolism and the development of obesity
Potential Benefits and Limitations of GLP-1 for Cognitive Function Emerging evidence from preclinical and early clinical studies suggests several potential cognitive effects of GLP-1 receptor agonists, though significant limitations remain in translating these findings to clinical practice
Translating a 15 mg/kg murine dose directly to humans underscores a severe translational gap in the source paper
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