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Description

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Tirzepatide, which acts on both GLP-1 and GIP receptors, generally produces greater weight loss in clinical trials compared to semaglutide alone

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Because pigmentation reflects downstream cellular changes rather than an immediate on/off response, observed effects are typically gradual and depend on individual biology, baseline skin type, UV exposure, and melanocyte activity

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(PubMed) However, while some small studies report mild pigment/lightening changes with glutathione (oral or topical), the clinical evidence for long-term, safe, and effective skin-whitening via IV glutathione is weak or absent

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