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Furthermore, pharmaceutical innovation has led to 29% improvement in drug efficacy, while manufacturing expansion has increased supply capacity by 41% between 2023 and 2025, addressing shortages affecting 33% of patients globally

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This linkage of Prx2 to the membrane appears to be through the N-terminal cytoplasmic domain of band 3, which is also the site of linkage of other cytoplasmic proteins, including metHb [98]