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Coagulation studies (INR, PTT)

This occurs through the direct impact of the peptide on body fat tissue, whereby it activates the beta-3 adrenergic receptor(s) involved in the fat-burning process within the body

The safety profile, optimal dosing strategies, and long-term effects in humans have not been fully established

Thus, modulating the Fc:FcRn interaction to prolong plasma half-life and attain a favorable biodistribution is a clinical success, and several clinical-stage candidate therapeutics harbor either the YTE or LS amino acid substitutions, or a more recently reported triple Fc mutant variant (Q311R/M428E/N434W