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In cultured neonatal rat cardiomyocytes, exogenous spermine attenuated myocardial injury induced by HG treatment, as demonstrated by restored cellular glucose uptake capacity, reduced expression of apoptotic markers, decreased levels of oxidative stress, ERS and the unfolded protein response, and upregulated cell membrane CaSR
The FDA has specifically approved certain versions (like Wegovy and Zepbound) for chronic weight management in people without diabetes, provided they have a certain BMI (usually 30+, or 27+ with a condition like high blood pressure)
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The natural decline in muscle mass (sarcopenia) that occurs with ageing leads to reduced metabolic rate, meaning fewer calories are burned at rest
