This hypothesis is supported by preclinical studies showing that early life traumatic stress is associated with chronic anxiety, spatial memory deficits and reduced expression of GABA A R subunits in the adult rat brains (351)
JAMA Intern Med 2016;176:1474-81.ArticlePubMed 38
Importantly, the largest reductions in BMI were observed in the southern United States, which also reported the highest rates of GLP-1 RA dispensing claims (Rader et al., 2024), a geographic concordance that is consistent with a causal contribution of these pharmacotherapies to the observed population-level BMI decline
Randomization and interventions Participants will be randomized in a 1:1 ratio using a random number generator to one of two semaglutide discontinuation strategies: (i) immediate cessation, in which participants will continue their current dose for 16 weeks followed by complete discontinuation, or (ii) gradual dose reduction, in which the semaglutide dosage will be reduced by 25% every 4 weeks until complete discontinuation at week 16
Researchers should evaluate their results around the four to six week mark to determine whether to continue, adjust, or discontinue their protocol