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Stress pathways induced by these factors, including endoplasmic reticulum stress, oxidative stress, mitochondrial dysfunction, and autophagy, are all involved in the induction of -cell apoptosis, and these pathways may occur simultaneously at the same level or may interact to further exacerbate -cell death in the form of superimposed harmful stress

The result is decreased appetite and reduced food consumption

A poor nights sleep can elevate your cortisol level, which disrupts hormones like progesterone and estrogen and affects your thyroid, slowing metabolism

It represents a dynamic equilibrium where the amount administered equals the amount eliminated, optimising blood glucose control and appetite regulation whilst minimising adverse effects

All authors contributed to interpretation of the data